ERK1 anticorps

N° du produit ABIN5702776

Cet anticorps Lapin Polyclonal détecte spécifiquement ERK1 dans WB, IHC, ELISA et IF. Il présente une réactivité envers Humain, Souris, Rat et Poisson zèbre (Danio rerio).

Aperçu rapide pour ERK1 anticorps (ABIN5702776)

Antigène: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-ERK1 anticorps

Fonction: ERK1/2 antibody

Immunogène: mitogen-activated protein kinase 1

Isotype: IgG

Information d'application

Indications d'application: WB : 1:1000-1:10000 IHC : 1:50-1:200 IF : 1:10-1:100

Commentaires:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab02845(ERK1/2 antibody) at dilution of 1:1000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ERK1

Antigène: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Autre désignation: ERK1

Sujet:

Synonyms: Mitogen-activated protein kinase 1 (MAP kinase 1, MAPK 1)|ERT1|Extracellular signal-regulated kinase 2 (ERK-2)|MAP kinase isoform p42 (p42-MAPK)|Mitogen-activated protein kinase 2 (MAP kinase 2, MAPK 2)|MAPK1|ERK2|PRKM1|PRKM2

Background: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Poids moléculaire: 38-44 kDa

UniProt: P28482

Pathways: Signalisation MAPK, Signalisation RTK, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteins